Researchers from the University of Luebeck have deciphered the code of the key enzyme responsible for the reproduction of SARS-CoV-2. Scientists have also found an inhibitor that is effective against the main coronavirus protease.
At the University of Lübeck, the scientists seem to have achieved a major breakthrough in the fight against the new coronavirus SARS-CoV-2, which causes SARS-CoVID-19 pneumonia. A team of researchers led by Professor Rolf Hilgenfeld deciphered the key enzyme code responsible for the reproduction of the SARS-CoV-2, the Donaukurier reported Monday, March 30.
The scientists also developed an inhalable inhibitor that works effectively against the main SARS-CoV-2 protease. The so-called viral main protease Mpro participates in the replication mechanism of coronavirus and, therefore, is responsible for copying genetic material and reproduction of SARS-CoV-2. The researchers have already successfully tested this inhibitor on mice and cell cultures against related coronaviruses.
“If we manage to block the main protease, we can prevent the virus from replicating,” said Professor Hilgenfeld. He also noted that it would take several years to create a drug based on an inhibitor.