Japanese specialists grew new teeth for mice

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Experts from Japan have developed a method by which lost teeth can be restored. They have carefully studied the process of teeth formation from a genetic point of view, paying special attention to the very first stages of their development. The results of their work have been published in Science Advances.

Scientists were able to find a specific gene that is responsible for the molecule that plays a leading role in the formation of teeth in the early stages of development. These are bone morphogenetic protein (BMP) and Wnt. In addition to teeth, he is responsible for the proper formation and development of various organs and tissues of the human body at the earliest stages of its formation.

But scientists were interested in the mechanism of its work to understand how these data can be used to regenerate teeth, if that will be possible. The first experiments were conducted on laboratory mice. And they showed that in rodents, the growth of new teeth is subordinated to the gene USAG-1.

It is this gene, interacting with the proteins BMP and Wnt, allows you to run the regenerative processes in terms of teeth. Research in this area will continue, because despite modern methods of prosthetics, “native” teeth, though re-grown, will still be considered a more reliable and less traumatic way to restore the masticatory apparatus.