A Russian-American team has created a new therapeutic method using nanoparticles of an antioxidant enzyme. It relieves inflammation and restores tissues without causing side effects such as irritation and allergies. The results are presented in the international journal Biomedicines.
As is known, one of the consequences of eye inflammation is the overproduction of reactive oxygen species (ROS), which often leads to damage to the organ epithelium, blurred vision and even blindness. A team of scientists from MISIS, Lomonosov Moscow State University, Helmholtz Research Center, and the University of North Carolina (USA) solved the problem of free radicals overproduction by creating polymeric superoxide dismutase enzyme nanoparticles (Nano-SOD1). In preclinical animal studies, administration of this drug was shown to be 35% more effective than other enzymes. Scientists observed a decrease in inflammation and restoration of antioxidant activity. Clinical trials of the drug are ahead.