Dental prosthetics often involves osteoplasty – transplanting a bone fragment from another part of the body or from an animal. Both options are not ideal, so experts from Russia have invented how to make the human body itself grow new bone tissue.
Doctor of Biological Sciences Dmitry Goldstein, head of the Laboratory of Stem Cell Genetics of the Botchkov Medical and Genetic Research Center, is working on the project. For the past five years, Goldstein, together with the staff of the Central Research Institute of Dentistry and Maxillofacial Surgery, has been trying to make the human body grow new bone tissue on its own.
“The materials used today provide approximately 35% of the bone tissue in the regenerate area. With autoplasty (when a small fragment of bone tissue is taken from a patient, shredded and placed in the defect area) we have about 60% new bone tissue. But autoplasty involves additional complications, so this method cannot be considered optimal. We go the way of growing new bone for dentures,” says Goldstein.
“If we take the morphogenetic protein BMP-2, which stimulates the growth of new bone tissue, as a basis, mesenchymal stem cells (MSCs) begin to turn into bone tissue cells. Experiments on animals and on cell cultures show that this is a very promising pathway,” the scientist added.